Hi Daniel,
Thank you for using Syncfusion product.
Yes. We can add multiple signature in PDF document without invalidating previous signatures. For this, we have use the licensed packages for creation to resolve this invalidate signature issue.
Note: Please make ensure whether you have using licensed assemblies. If you are using trial version, it will invalidate the older signature because of adding watermark to PDF.
Please let us know if you need any further assistance on this.
Regards,
Gowthamraj K