Hi Nitroxn,
Thank you for using Syncfusion products.
Yes. It is possible and this can be done by setting the property InteractiveCheckBox of TreeNodeAdv to true as follows.
[C#]
treeNodeAdv1.InteractiveCheckBox = true;
Please find the sample below that demonstrates this and let me know if this helps you.
http://files.syncfusion.com/support/Tools.Windows/7.2.0.20/F82389/Tools_WF_TreeView_InteractiveCheckBox.zipRegards,
Jaya