Hi Mark,
Thank you for using Syncfusion products.
To programmatically select a node, use the code snippet below.
this.treeViewAdv1.SelectedNode = this.treeViewAdv1.Nodes[1];
To highlight the selected node, you can go with the properties SelectedNodeForeColor and SelectedNodeBackground.
Please refer the sample below and let me know if you have anyother queries.
http://websamples.syncfusion.com/samples/Tools.Windows/F62790/main.htmRegards,
Jaya