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//in form load this.gridListControl1.Grid.QueryCellInfo += new Syncfusion.Windows.Forms.Grid.GridQueryCellInfoEventHandler(grid_QueryCellInfo); //the handler private void grid_QueryCellInfo(object sender, Syncfusion.Windows.Forms.Grid.GridQueryCellInfoEventArgs e) { //ID the rows to be disabled somehow... if(e.RowIndex > 0 && e.RowIndex % 3 == 0) { e.Style.BackColor = Color.Gray; e.Style.Enabled = false; e.Handled = true; } } //derived class with override public class MyGridListControl : GridListControl { protected override void OnMouseUp(System.Windows.Forms.MouseEventArgs e) { if(e.Button == MouseButtons.Left) { int row = this.Grid.TopRowIndex + this.Grid.ViewLayout.PointToClientRow(new Point(e.X, e.Y)) - 1; if( this.Grid[row, 1].Enabled == false) return; } base.OnMouseUp(e); } }