It is possible to set different colors to the Columns in a series by two ways:
1. Using the Series.Styles[index]:
For example, if a Series contains 3 Columns/Bar, each column/Bar can be set different colors using Styles property of the series as follows.
Series.Styles.Interior = new BrushInfo(Color.Blue);
Series.Styles.Interior = new BrushInfo(Color.Green);
Series.Styles.Interior = new BrushInfo(Color.Red);
Please refer to following sample that illustrates the same.Sample 1
2. Using PrepareStyle event:
Please refer to the following link for more information on this event.http://websamples.syncfusion.com/docs/chart/ug/PrepareStyleEvent.html
I have attached a sample illustrating the same in the below link.Sample 2
Please let me know if you need any other informtaion.
Thanks for your interest in Syncfusion products.