Hi Asad,
Thanks for contacting Syncfusion Support.
We can block the weekenddays by using “BlockOutDates property” in Calendar control. To achieve you requirement we can use the OnMonthLoaded event and add the weekenddates to the BlackoutDates collection. While creating the same, we have faced some issue “ able to select the blockout dates also”. A support incident to track the status of this defect has been created under your account. Please log on to our support website to check for further updates.
https://www.syncfusion.com/account/login?ReturnUrl=%2fsupport%2fdirecttrac%2fincidents/ Regards,
Hemalatha M.R.