Hi Mark,
Thanks for contacting Syncfusion support.
Web Application will work fine on 64bit machine, can you please check your configuration, whether all the dll files required for the projects are present in the machine? Please provide information regarding the issue you are facing currently in detail with screenshots of error messages.
We found a useful article in the web, hope this might help you:
Please get back to us with the requested details.
Regards,
Prince