Hi Scott,
You can programmatically blank out the combo box by setting the text property to null after setting the data source.
Below is the code snippet:
this.multiColumnComboBox1.DataSource=mt;
this.multiColumnComboBox1.DisplayMember="ProductID";
this.multiColumnComboBox1.ValueMember = "ProductName";
this.multiColumnComboBox1.Text = null;
Please refer the sample and let us know if this helps.
http://websamples.syncfusion.com/samples/Tools.Windows/F70909/main.htmKindly let us know if you need any further assistance.
Thank you for using Syncfusion Products.
Best Regards,
Jeba.