Hi Ken,
You can handle the CurrentCellValidating event of the grid to validate the contents and handle the CurrentCellAcceptedChanges event to rebind the grid with the new datatable.
Please try the attached sample that demonstrates the way you could do this. When you run the sample, try entering some continent names for the string value types(that displays continents in cells), you can notice that grid gets rebinded with new datatable.
Here is the sample
Forum_47622.zip
'>http://www.syncfusion.com/Support/user/uploads/Forum_47622_3e18ed5d.zip">Forum_47622.zip
Let me know if this helps.
Thanks,
Rajagopal