Hi Shanuka,
Thank you for contacting Syncfusion Support.
Based on the provided information, we have checked the mentioned issue and we unable to replicate it from our end. SfPopupLayout did not closes at once it is opened and it works fine as expected. We had tested by loading a label in the content template.
We have attached the sample for your reference,
Please check the sample and let us know if you still facing the same issue? If not, please modify the sample based on your scenario and revert us with more details. It will be helpful for us to check on it and provide you the solution at the earliest.
Regards,
Subburaj Pandian V