Hi Danny,
Thanks for contacting Syncfusion support.
We have checked the reported issue with Xamarin.Forms v3.0 and SfDataGrid v16.1.0.37, also used Prism but while navigating back we did not face any issues. For your reference we have attached working copy of the sample in the below location, please refer it. Our latest SfDataGrid version will support Xamarin.Forms v2.4.0.280. We are going to provide Xamarin.Forms v3.0 in our upcoming 2018 Vol 2 main release, which is scheduled to be rolled out by the Mid of June, 2018. We will update you once release gets rolled out. We request you to use supported Xamarin.Forms version instead of using latest Xamarin.Forms version. If the issue persists, please modify our attached sample based on your requirement and revert along with replication procedure, that would be more helpful to analyse further.
Regards,
Ashok