Hi Chen,
Thank you for using Syncfusion products.
Essential XlsIO supports for opening the excel file with macros in it. Essential XlsIO does not support to make a call to macro in Excel.
However, we could see the query is related to the below forum and we request you to follow up the below forum for further more updates.
http://www.syncfusion.com/support/forums/general/110910
Thanks,
Sridhar.S