How do I position my form to the bottom right of the screen when it opens up the first time above the system tray?

Do as follows in your Form’s constructor after setting the StartPosition to Manual:

[C#]
this.SetBounds(Screen.GetWorkingArea(this).Width-this.Width
			,Screen.GetWorkingArea(this).Height-this.Height , this.Width, this.Height);

[VB.Net]
Me.SetBounds(Screen.GetWorkingArea(Me).Width-Me.Width
				,Screen.GetWorkingArea(Me).Height-Me.Height , Me.Width, Me.Height)