The issues listed here are pertaining to code running in IE in the default Internet Zone.
1) You cannot view Controls inside IE using the 1.0 framework (when running with the permissions in the default Internet Zone). This is however possible with the 1.1 (Everett) framework.
2) Use only one . in the assembly file name and ‘Assembly Name'(in Project Properties Dialog). For example, ‘Syncfusion.Shared.dll’ is an invalid dll name, but ‘Shared.dll’ is valid.
3) Signed assemblies couldn’t be loaded.