By default, the ContextMenuStrip opens only on right click over the associated control. When the cell is in edit mode, it no longer receives mouse-related events. The control (TextBox or ComboBox) present in the cell alone receives the mouse events. So to have a ContextMenuStrip in the edit mode, you need to set the ContextMenuStrip for those controls present in the cell. This can be achieved by handling the events CurrentCellControlGotFocus, CurrentCellControlLostFocus and MouseDown.
Refer to the following C# and VB samples.
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