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<syncfusion:SplitButtonAdv Command="{Binding MyCommand}" ... />
If MyCommand is a custom ICommand (not a RoutedCommand), as soon as the CanExecute on the command is set to false, the SplitButtonAdv is disabled and is never re-enabled, even after subsequent changes to ICommand.CanExecute. In particular, this means that such a command can only be executed once, if its CanExecute is set to false while executing.